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COLORECTAL CANCER  

By A. Qureshi,

Consultant General & Colorectal Surgeon, Sunway Medical Centre, Petaling Jaya

Colorectal cancer is the third most common cause of cancer deaths in Malaysia. Data from the Ministry of Health Malaysia confirms an increase of colorectal cancer admission rate from 8.1% (1973 cases) in 1987 to 11.9% (4215 cases) in 1995. Rectal cancer alone constituted for 50% of colorectal admission and colorectal cancer deaths.  The incidence of colorectal cancer in Malaysia is 10-15 cases per 100,000. The mean age at presentation in the western developed nations is 60-65 years. However, in Malaysia this figure is approximately 10 years earlier. There is evidence to suggest that colorectal carcinoma is more common amongst the Chinese while the age of presentation is earlier amongst the Malays, and other indigenous groups of East Malaysia.

WHO IS AT RISK OF COLORECTAL CANCER?
Although colorectal cancer may occur at any age, more than 90% of patients with colorectal carcinoma are over age 40, at which point the risk doubles every ten years. Important risk factors other than age include a family history of colorectal cancer and polyps and a personal history of ulcerative colitis, colon polyps or cancer of other organs, especially of the breast or uterus.
 

HOW DOES COLORECTAL CANCER START?

Most colon and rectal cancers start as small growths called polyps. These are pre-malignant (benign) growths that occur on the bowel wall and may eventually increase in size and become cancer. Removal of these benign polyps while can prevent the development of colorectal cancer. 

 

WHAT ARE THE SYMPTOMS OF COLORECTAL CANCER?
The most common symptoms are an alteration in bowel habit such as constipation, rectal bleeding and a sensation of incomplete emptying of the bowels. It is important to note that these symptoms are also common in other diseases, so it is important that the patient receives a thorough examination by a specialist should these symptoms be present. Abdominal pain and weight loss are usually late symptoms indicating possible extensive disease.  Many polyps and early cancers fail to produce symptoms and thus it is important that if the patient has any of the risk factors, a specialist consultation is made.
 

WHAT IS CONSTIPATION?
Constipation is a symptom that has different meanings to different individuals. Most commonly, it refers to infrequent bowel movements, but it may also refer to a the passage of hard motions, a decrease in the volume of stool, the need to strain to have a bowel movement, a sense of incomplete evacuation, or the need for enemas, suppositories or laxatives in order to maintain regularity. About 80 percent of people suffer from constipation at some time during their lives, and brief periods of constipation are normal.  Constipation may be diagnosed if bowel movements occur fewer than three times weekly on an ongoing basis.
 

WHEN SHOULD I SEE A DOCTOR ABOUT CONSTIPATION?
Any persistent change in bowel habit - increase or decrease in frequency or size of stool or an increased difficulty in evacuating - warrants medical advice. Whenever constipation symptoms persist for more than three weeks, you should consult your doctor. If blood appears in the stool, consult your specialist right away.
 

HOW IS COLORECTAL CANCER TREATED?

Colorectal cancer requires surgery in nearly all cases for complete cure. In some patients, radiotherapy and chemotherapy are sometimes used in addition. In the early stages of colorectal cancer, 80-90% is cured if the cancer is detected and treated.  However, the cure rate drops to 50% or less when diagnosed in the later stages.  Only a small number of patients, less than 5% of all colorectal cancer patients, require a stoma, the surgical construction of an artificial bowel opening on the abdomen.  

 

WHAT IS A STOMA?
A stoma is a man made opening of the bowel to the surface of the abdomen.  The most common types of stoma in intestinal surgery are an "ileostomy" (connecting the small intestine to the skin) and a "colostomy" (connecting the large intestine to the skin).  A stoma may be temporary or permanent. A temporary stoma can be closed at a second operation a few months later.  A permanent stoma may be required when disease, or its treatment, impairs normal intestinal function, or when the muscles that control the anus do not work properly or require removal. The most common cause of this is due to a low rectal cancer.
 

 

CAN COLON CANCER BE PREVENTED?

Prevention of colorectal cancer can be attempted in two ways, modification of diet and colonoscopic intervention.  A high fiber, low animal fat diet is the only dietary measure that helps prevent colorectal cancer.   Once polyps are detected at colonoscopy, a simple outpatient procedure of removing these polyps during the colonoscopy can reduce the risk of developing colorectal cancer.
 

WHAT IS A COLONOSCOPY?
Colonoscopy is a method of looking at the lining of the colon and rectum.  It is a simple, safe and effective means of visually examining the entire lining of the colon and rectum, using a long, flexible, tubular instrument. It is used to diagnose colon and rectum problems as well as to perform biopsies and remove colon polyps. Most colonoscopies are done on an outpatient basis, under sedation, with minimal inconvenience and discomfort.
 

WHO SHOULD HAVE A COLONOSCOPY?
A colonoscopy is performed on patients with suspected colon and rectum problems.  Patients with the following symptoms are usually advised to undergo a colonoscopy:

  • Rectal bleeding
  • Altered bowel habit
  • To confirm findings of polyps or tumors located with a barium enema exam
  • Monitor patients with a past history of colon polyps or cancer
  • Examine patients who test positive for blood in the stool


HOW IS COLONOSCOPY PERFORMED?

Prior to a colonoscopy, the bowel must first be thoroughly cleansed of all fecal residue. This is done either the evening before or the morning of the colonoscopy. Sedation is given prior to the colonoscopy to relieve anxiety and discomfort.  The colonoscope is inserted through the anus and carefully guided through the entire length of the large bowel (colon & rectum).  When required, polyps can be removed or biopsies taken.

 

The entire procedure usually takes 10-20 minutes. Following the colonoscopy, there may be some slight discomfort due to the gas insufflation during the colonoscopy.  This quickly improves with the expulsion of the gas. The patients can resume their regular diet later that same day.  

 

CAN HEMORRHOIDS LEAD TO COLON CANCER?
No, but hemorrhoids may produce symptoms similar to colon polyps or cancer. Should you experience these symptoms, you should have them examined and evaluated by a specialist without delay.  

Editor’s note:
There are other tests for screening for colon cancer. The barium enema used to be the primary method until the advent of colonoscopy. Now, virtual colonoscopy (CT scan images of the abdomen with computer reconstruction of the colon) is being studied for its ability to screen for colon cancer as well.
 

For more information –
http://www.cancer.gov/cancerinfo/types/colon-and-rectal

National Cancer Institute of America’s website with information about detection, symptoms, diagnosis, and treatment of colon and rectal cancer 

 

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Last Updated:
Thursday, 21 August, 2003