Digital mammography offers fundamental advantages over film-based mammography. These include the possibility for acquiring quality images at lower radiation dose image recording, processing and archiving as well as the use of artificial intelligence for improving diagnostic outcome. Other practical advantages include cost reduction, use of environmentally friendly technology, and the option of obtaining remote expert diagnostic opinion. Image quality in mammography is critical. A switch from screen-film technology to a digital system is preferable only if high quality images can be guaranteed. This publication provides guidance on the establishment of digital mammography facilities and the upgrade of existing facilities. It focuses on planning, designing and operating the high quality mammography service within available resources.